Yoshimi Imura Selected Research

1- ((1- (3- acetoxy- 2,2- dimethylpropyl)- 7- chloro- 5- (2,3- dimethoxyphenyl)- 2- oxo- 1,2,3,5- tetrahydro- 4,1- benzoxazepin- 3- yl)acetyl)piperidine- 4- acetic acid

12/2003	Comparing myotoxic effects of squalene synthase inhibitor, T-91485, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in human myocytes.
7/2003	Lipid-lowering properties of TAK-475, a squalene synthase inhibitor, in vivo and in vitro.
4/2003	Lipid-lowering effects of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia.

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Yoshimi Imura Research Topics

Disease

1	Acute Coronary Syndrome 01/2018
1	Hypertension (High Blood Pressure) 12/2011
1	Heart Failure 12/2011
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2011
1	Body Weight (Weight, Body) 05/2009
1	Glucose Intolerance 05/2007
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 05/2007
1	Insulin Resistance 05/2007
1	Myotoxicity 12/2003
1	Rhabdomyosarcoma 12/2003
1	Dyslipidemias (Dyslipidemia) 07/2003
1	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 04/2003
1	Proteinuria 03/2002
1	Hypercholesterolemia 03/2002
1	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 03/2002

Drug/Important Bio-Agent (IBA)

3	1- ((1- (3- acetoxy- 2,2- dimethylpropyl)- 7- chloro- 5- (2,3- dimethoxyphenyl)- 2- oxo- 1,2,3,5- tetrahydro- 4,1- benzoxazepin- 3- yl)acetyl)piperidine- 4- acetic acidIBA 12/2003 - 04/2003
2	candesartan cilexetil (Amias)FDA Link 05/2007 - 03/2002
2	LipidsIBA 12/2003 - 04/2003
1	Thrombin FDA Link 01/2018
1	Thrombin Receptors (Thrombin Receptor)IBA 01/2018
1	Factor Xa (Coagulation Factor Xa)IBA 01/2018
1	PAR-1 ReceptorIBA 01/2018
1	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 12/2011
1	gamma-Aminobutyric Acid (GABA)IBA 05/2009
1	candesartanIBA 05/2007
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 05/2007
1	azilsartanIBA 05/2007
1	Glucose (Dextrose)FDA LinkGeneric 05/2007
1	Insulin (Novolin)FDA Link 05/2007
1	Mevalonic Acid (Mevalonate)IBA 12/2003
1	Coenzyme A (CoA)IBA 12/2003
1	SqualeneIBA 12/2003
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2003
1	LDL Lipoproteins (beta Lipoproteins)IBA 04/2003
1	LDL Receptors (LDL Receptor)IBA 04/2003
1	AcidsIBA 04/2003
1	Farnesyl-Diphosphate Farnesyltransferase (Squalene Synthase)IBA 04/2003
1	Enalapril FDA LinkGeneric 03/2002
1	Angiotensin IIIBA 03/2002

Therapy/Procedure

2	Therapeutics 01/2018 - 12/2003